Yvonne Zissiadis trained as a Radiation Oncologist at the Peter MaCallum Cancer Institute, Melbourne, Australia. This was followed by a Fellowship in Breast Cancer at the Breast Cancer Institute of Australia, NSW. She then commenced work as a radiation oncologist at the Prince of Wales Hospital, Randwick, NSW. In 1999, Yvonne completed a fellowship at the Massachusetts General Hospital and then returned to her home town of Perth, Western Australia to take up the position of radiation oncologist at Royal Perth Hospital and Perth Radiation Oncology. This then became Fiona Stanley Hospital and Genesiscare WA.
Her other activities include membership of the RANZCR Education and Training committee, RANZCR Radiation Oncology Research Committee, TROG, BTG, ASTRO and ESTRO. She holds conjoint lectureship positions with the University of Western Australia and Edith Cowen University. From 2015, she has held the position of President of the Australasian Society of Breast Disease. She has contributed to the organisation of a number of conferences, teaching courses and workshops as well as registrar teaching.