Prudence Francis commenced Medical Oncology training in Australia and subsequently completed training in the USA. She spent 4 years at Memorial Sloan-Kettering Cancer Center in New York. In 1994 she was appointed as a Consultant Medical Oncologist at the Peter MacCallum Cancer Centre in Melbourne. Since 2003 she has been the Clinical Lead for Breast Medical Oncology at Peter MacCallum. She is Chair of the Scientific Advisory Committee of the Australia New Zealand Breast Cancer Trials Group (ANZ BCTG). She is a member of the Scientific Committee of the International Breast Cancer Study Group (IBCSG). She is a panel member on the Advanced Breast Cancer (ABC) International Consensus Panel and the St Gallen International Consensus Panel for Primary Therapy of Early Breast Cancer. As a clinician researcher she has focused much of her research on randomized breast cancer trials.